Overview

The Association Statistics module leverages the fine-mapping power of high-density genotyping platforms to make statistical associations between genotype calls and the studied affectation. The Assoication Statistics module is a core component of the Exemplar Analytics Suite and is fully integrated with the other analysis modules. Because of this tight integration, scientists may view the results of statistical genetics analysis simultaneously with the results of our artificial intelligence analysis. The association study analyses performed by this module are standard statistics implemented in a clear and easy-to-use graphical user interface.

Statistics

Exemplar's Association Study statistical analysis methods comprise an integrated computational tool that provides a host of traditional association statistics, such as:

• Hardy-Weinberg

• Minor Allele Frequency
• Chi Square
• Odds Ratio
• Fishers Exact
• G-Test
• Relative Risk

• Trend Test

Statistics are computed by genotype, by allele, or for the whole SNP. These statistics pinpoint genomic regions of interest from any high density genotyping project.

Error Correction

In addition, error corrections are performed on certain statistics, including:

• Multiple Testing Permutation Correction

• False Discovery Rate

• Bonferonni

Results

The results are displayed in unmatched graphical clarity to ease interpretation of results. The Association Statistics module also produces tabular reports with the results of the analyses. The detailed displays provide interactive filtering and viewing of results to enable users to drill down to the significant elements in the study.