Approach
Haplotype analysis is becoming increasingly important in studying genetic diseases, especially in light of the recent increase in the abundance of high-density SNP data.
Haplotype information can provide valuable insight when researching the role of a group of candidate SNP's or genes in the origins of complex diseases. Exemplar employs the widely accepted method for deducing haplotypes from collections of genotypes in the absense of family data using the statistical method known as the Expectation-Maximization (EM) algorithm.
The EM algorithm is a maximum likelihood algorithm used in assocation-based studies to infer haplotypes from genotypic data and test their association with a phenotype of interest. |
